Timothy D. Mickleborough
Assistant Professor and Director of Graduate Studies
- Ph.D. at Colorado State University, 2000
- M.S. at Colorado State University, 1997
- M.App.Sc at University of NSW, Australia, 1990
- B.Eng at University of Nottingham, 1985
- Fellow of the American College of Sports Medicine
- Member of the American Thoracic Society
- Full Member and Accredited Sport & Exercise Scientist (Physiology-Research) of the British Association of Sport and Exercise Sciences (BASES)
- Regular Member of the American Physiological Society (APS)
- Grant Reviewer, Canadian Institutes of Health
My main research interests focus on the effect of nutrition on physiological function and respiratory muscle function in health and disease. My research group has demonstrated that dietary modification has potential to reduce the severity of exercise-induced bronchoconstriction (EIB). For example, we have recently demonstrated that a low sodium diet reduces post-exercise induced airway narrowing and moderates airway inflammation in asthmatic subjects with EIB. In addition, we have also shown recently that a three-week fish oil diet, rich in omega-3 polyunsaturated fatty acids, has a protective effect in suppressing EIB in asthmatic subjects and elite athletes. This work has resulted in numerous grant applications currently under consideration at the National Institutes of Health (NIH). Research related to respiratory muscle function in my laboratory is currently directed at assessing respiratory muscle and pulmonary function characteristics of elite swimmers. We have previoulsy shown that inspiratory muscle training improves inspiratory muscle strength and endurance and exercise capacity in recreational runners.
Mickleborough, T. D., Murray, R. L., Ionescu, A. A., & Lindley, M. R. (2003). Fish oil supplementation reduces severity of exercise-induced bronchoconstriction in elite athletes. American Journal of Respiratory and Critical Care Medicine, 168 (10), 1181-1189.
Mickleborough, T. D., Lindley, M. R., & Ray, S. (2005). Dietary salt, airway inflammation and diffusion capacity in exercise-induced asthma. Medicine & Science in Sports & Exercise, 37(6), 904-914.
Ray, S., Mickleborough, T. D., & Brown, J. L. (2005). Comparison of the properties of rare variants of α1-proteinase inhibitor expressed in COS-1 cells and assessment of their potential as risk factors in human disease. Biochimica et Biophysica Acta - Molecular Basis of Disease, 1740 (3), 390-402.
Mickleborough, T. D., & Rundell, K. W. (2005). Dietary polyunsaturated fatty acids in asthma and exercise-induced bronchoconstriction. European Journal of Clinical Nutrition, 59 (12), 1335-1346.
Karp, J. R., Johnston, J. D., Tecklenburg, S., Mickleborough, T. D., Fly, A., & Stager, J. M. (2006). Chocolate milk as a post-exercise recovery aid. International Journal of Sport Nutrition and Exercise Metabolism, 16 (1),78-91.
Mickleborough, T. D., Ionescu, A. A., Lindley, M. R., & Fly, A. D. (2006). Protective effect of fish oil supplementation on exercise-induced bronchoconstriction in asthma. Chest, 29 (1), 39-49.
Stanford, K. I., Mickleborough, T. D., Ray, S., Lindley, M. R., Koceja, D. M., & Stager, J. M. (2006). Influence of menstrual cycle phase on pulmonary function in asthmatic athletes. European Journal of Applied Physiology, 96 (6), 703-710.
Ionescu, A. A., Mickleborough, T. D., Bolton, C. E., Lindley, M. R., Nixon, L. S., Dunseath, G., Luzio, S., Owens, D. R., & Shale, D. J. (In Press). The systemic inflammatory response to exercise in adults with cystic fibrosis. Journal of Cystic Fibrosis.
Courses Recently Taught
HPER K535 Physiological Basis of Human Performance
HPER K638 Biochemical Adaptations to Exercise
HPER K639 Laboratory Techniques for Exercise Biochemistry
HPER P409 Basic Exercise Physiology